Kisspeptin, unexplained infertility and embryo implantation
نویسندگان
چکیده مقاله:
Objective The primary objective of the study was to compare baseline KP levels in females with different causes of infertility and then correlate it with the risk of failure to conceive, preclinical abortion and pregnancy after intracytoplasmic sperm injection (ICSI). MaterialsAndMethods AA longitudinal cohort study was carried out from August 2014 till May 2015 recruiting one hundred and twenty-four patients of ICSI, after obtaining ethical approval from Australian Concept Infertility Medical Centre. Cause of infertility in 124 females due to male, female and unexplained causes was; 32 (24%), 33 (31%) and 59 (45%). KP levels were measured by ELISA assay before the initiation of ICSI treatment protocol. Outcome of ICSI was declared in groups; non-pregnant with beta human chorionic gonadotropin (β HCG) 25mIU/ml with no cardiac activity and clinical pregnancy declared upon confirmation of cardiac activity. Results on the basis of cause of infertility and outcome groups were compared by One Way Analysis of Variance. Results Unexplained infertile females had significant low levels of KP as compared to male factor infertility cause (176.69± 5.03 vs. 397.6 ± 58.2, p=0.001). Clinical pregnancy was acquired by 28 (23%) females out of which 17 (71%) had a female cause of infertility. In non-pregnant group of 66 (53%) females, common cause of infertility was unexplained 56(85%). A weak positive correlation of KP with fertilized oocytes and endometrial thickness (p=0.04 and 0.01 respectively) was observed. Conclusion Deficiency of KP in females with unexplained infertility was associated with reduced chances of implantation after ICSI.
منابع مشابه
Kisspeptin: A Potential Factor for Unexplained Infertility and Impaired Embryo Implantation
BACKGROUND Kisspeptin (KP) is a neuropeptide that causes the release of the gonadotropin releasing hormone, which controls hypothalamo pituitary ovarian axis and exerts a number of peripheral effects on reproductive organs. The primary objective of this study was to compare baseline KP levels in females with different types of infertility and identify possible correlations with risk of failure ...
متن کاملOverexpression of Endometrial Estrogen Receptor-Alpha in The Window of Implantation in Women with Unexplained Infertility
Objective Background: Failure in the endometrial receptivity may account for a significant number of infertility cases including unexplained infertility in women. Reduction in the endometrial estrogen receptor-alpha (ER-α) expression during window of implantation may be a critical event that coincides with expression of specific genes and providing a receptive endometrium. The aim of present st...
متن کاملDexamethasone in unexplained infertility.
OBJECTIVE To determine if dexamethasone could be a suitable option in the treatment of patients with unexplained infertility. METHODS This study was carried out in the Obstetrics Department of Amir University Hospital, Semnan, Iran, from April 2001 to May 2008. One hundred and twenty-four cases of unexplained infertility that underwent ovulation induction and intrauterine insemination (IUI) (...
متن کاملThe role of thrombophilia and thyroid autoimmunity in unexplained infertility, implantation failure and recurrent spontaneous abortion.
BACKGROUND The role of thrombophilia and thyroid autoimmunity in unexplained infertility (UI), implantation failure (IF) and recurrent spontaneous abortion (RSA) is controversial and poorly understood. METHODS From March, 2004 to January, 2007, 119 women were prospectively included: 32 oocyte donors, 31 patients with UI, 26 with IF and 30 with RSA. The IF and RSA groups presented normal preim...
متن کاملDemographics of infertility and management of unexplained infertility.
The cause of infertility is unexplained in about 22-28% of all infertile couples. The prognosis for spontaneous pregnancy in such couples is better than in those with diagnosed causes of infertility. Traditional treatment options in this group have included expectant management, clomifene citrate, intrauterine insemination with (super ovulation plus intrauterine insemination) or without (intrau...
متن کاملمنابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ذخیره در منابع من قبلا به منابع من ذحیره شده{@ msg_add @}
عنوان ژورنال
دوره 11 شماره 2
صفحات 99- 104
تاریخ انتشار 2017-07-01
با دنبال کردن یک ژورنال هنگامی که شماره جدید این ژورنال منتشر می شود به شما از طریق ایمیل اطلاع داده می شود.
میزبانی شده توسط پلتفرم ابری doprax.com
copyright © 2015-2023